Kamil Nosol

Address

ETH Zürich
Institut für Molekularbiologie und Biophysik
Professur Molekulare Membranbiologie
Otto-Stern-Weg 5 / HPK G 14.1
8093 Zürich
Switzerland

+41 44 633 62 79

Curriculum vitae

Publications

Ciuta AD*, Nosol K*, Kowal J*, Mukherjee S*, Ramirez AS, Stieger B, Kossiakoff AA, Locher KP; Structure of human drug transporters OATP1B1 and OATP1B3; Nature Communication, 2023; 14, 5774.

Liu H, Irobalieva RN, Kowal J, Ni D, Nosol K, Bang-Sørensen, Lancien L, Stahlberg H, Stieger B, Locher KP; Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP; Nature Communication; 2023; 14, 7296.

Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M; Antiviral HIV-1 SERINC Restriction Factors Disrupt Virus Membrane Asymmetry; Nature Communication, 2023, 14, 4368.

Ashraf KU, Rie Nygaard R, Vickery ON, Erramilli SK, Herrera CM, McConville TH, Petrou VI, Giacometti SI, Dufrisne MB, Nosol K, Zinkle AP, Graham CLB, Loukeris M,  Kloss B, Skorupinska-Tudek K, Swiezewska E, Roper DI, Clarke OB, Uhlemann A-C, Kossiakoff AA, Trent MS, Stansfeld PJ, Mancia P; Structural basis of Lipopolysaccharide Maturation by the O-Antigen Ligase; Nature, 2022, 604, pages 371–376.

*Ramirez AS, *Nosol K, Locher KP, Production of Human ABC Transporters and Oligosaccharyltransferase Complexes for Structural Studies. Methods Mol Biol, 2022; 2507:273-​294.

Liu H, Irobalieva RN, Bang-​Sørensen R, Nosol K, Mukherjee S, Agrawal P, Stieger B, Kossiakoff AA, Locher, KP. Structure of human NTCP reveals the basis of recognition and sodium-​driven transport of bile salts into the liver. Cell Research, 2022, 32, 773-775.

Urgaonkar S, Nosol K, Said AM, Nasief NN, Bu Y, Locher KP, Lau JYN, Smolinski MP; Discovery and Characterization of Potent Dual P- Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo- EM Analysis, and Biological Evaluations; J. Med. Chem, 2022; 65(1):191- 216.

Nosol K, Bang-Soerensen R., Irobalieva RN, Erramilli SK, Stieger B, Kossiakoff AA, Locher KP; Structures of ABCB4 provide insight into phosphatidylcholine translocation; PNAS, 2021; 118(33).

Pobudkowska A, Sliwinska A, Nosol K; Physicochemical Properties and Solubility of Hydrochloride Mucolytic Agents; Journal of Solution Chemistry, 2021; 50: 652-666

Nosol K, Romane K, Irobalieva RN, Alam A, Kowal J, Fujita N, Locher KP.
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1; PNAS, 2020; 117(42).

Bloch JS, Pesciullesi G, Boilevin J, Nosol K, Irobalieva RN, Darbre T, Aebi M, Kossiakoff AA, Reymond JL, Locher KP; Structure and mechanism of the ER-based glucosyltransferase ALG6; Nature, 2020; 579:443-447.

Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, Quick M, Fidock DA, Mancia F; Structure and drug resistance of the Plasmodium falciparum transporter PfCRT; Nature, 2019; 576:315-320.

Pobudkowska A, Nosol K, Gierycz P, Domańska U; Formulation of nimesulide-loaded polylactide/poly(lactic-co-glycolic acid) nanoparticles and the evaluation of release kinetics; Polimery, 2018; No 9, 586.

Bogel-Łukasik E, Nosol K, Silva D, Melo CI; Catalytic hydrogenation for a biomass-derived dicarboxylic acid valorisation with an ionic liquid and CO2 towards a perspective host guest building block molecule; The Journal of Supercritical Fluids, 2018; 133: 542-547.

Pobudkowska A, Szabłowska A, Nosol K; Physicochemical properties and solubilities of drugs hydrochlorides in water and alcohols; International Journal of Pharma Research & Review, 2016; 5(2):19-32.

 

Patent

Ewa Bogel-Łukasik, Kamil Nosol; 2018; Método de síntese de 9-tiabiciclo[3.3.1]nonano-2,6-diona recorrendo a ácido sucínico num meio com dióxido de carbono e num líquido iónico proveniente de biomassa, realizado num único passo
(eng. One-pot method of synthesis of 9-thiabicyclo[3.3.1]nonane-2,6-dione); Portugal 109432 B filled 07.06.2016 and issued 24.07.2018.

Conferences


Kamil Nosol
, GRS talk, GRC poster: “Structural and Functional Comparison of the Multidrug Transporter ABCB1 and the Phosphatidylcholine Translocator ABCB4”; GRC Ligand Recognition and Molecular Gating; 19-25 March 2022; Renaissance Tuscany Il Ciocco, Lucca (Barga), Italy

Kamil Nosol, short talk: “Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1”, GRC Connects: Multi-drug efflux system; May 2021.

Kamil Nosol, Satchal Erramilli, Przemyslaw Dutka, Anthony Kossiakoff;“Structure determination of membrane proteins embedded in nanodiscs complexed with synthetic antibodies”; Frontiers in membrane Protein Structural Dynamics; 10–12 November 2017; Argonne National Laboratory, Lemont IL, US.  

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